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Odds, Picks, Line, and Spread for Kansas City Chiefs vs. San Francisco 49ers on August 14, 2021 | NFL preseason 2021

Jimmy Garoppolo and the Patriots will make their preseason debut against Patrick Mahomes and the Chiefs on Saturday night.
Both Garoppolo and Mahomes will start for their respective teams, but just for the opening drive.
To conclude the first half of the preseason opener, San Francisco will turn to rookie quarterback Trey Lance.
Clyde Edwards-Helaire, the Chiefs’ second-year running back, will also be in attendance.
There’s a lot of anticipation for the 49ers-Chiefs game on Saturday night.
The game between the Chiefs and Niners is expected to draw a large crowd, with Mahomes and Garoppolo starting, Trey Lance making his debut, and Clyde Edwards-Helaire looking to have a breakout season.
Kansas City Chiefs vs. Washington Redskins
San Francisco 49ers Betting Odds The 49ers open their preseason against the Kansas City Chiefs as -2.0 favorites at home.
The over/under for the Chiefs-49ers game is set at 39 at Caesars Sportsbook.
Trey Lance makes his first appearance at Levis Stadium #49ers — David Lombardi (@LombardiHimself) August 7, 2021 Kansas City Chiefs vs. San Francisco 49ers
Picks for the San Francisco 49ers — Patrick Mahomes throws a touchdown pass on the first drive.
— Jimmy Garoppolo appears to be in good health but fails to score on his first drive.
— Trey Lance will suffer at first, but he will overcome it.
Lance will throw for a score and over 100 yards.
— Kyle Shanahan will get a closer look at Trey Lance’s movement on the field.
— Clyde Edwards-Helaire scores on the ground.
— On the defensive side of the ball, both the 49ers and the Chiefs will discover their flaws.
Kansas City Chiefs vs. Washington Redskins
Money Line: San Francisco 49ers (-135) Kansas City Chiefs (+115) Today was our final workout before our first preseason game against the 49ers.
Here’s what you might have missed. — Kansas City Chiefs (@Chiefs) August 12, 2021
San Francisco 49ers Spread The San Francisco 49ers had an overall record of 7-9-0 against the spread in the 2020 season.
Last season, San Francisco only covered the spread twice at home, compiling a 2-6-0 ATS record.
The 49ers went 5-3-0 against the spread on the road this season.
In 2020, the Kansas City Chiefs were likewise 7-9-0 against the spread.
The Chiefs failed to reach.500 against the spread despite having the greatest win-loss record in the NFL.
Kansas City had a 3-5-0 home record and a 4-4-0 road record against the spread.
Both teams struggled last season, and with the preseason underway, it’s difficult to predict who will cover the spread.
Prem Deshpande edited the piece.